Home Betting Picks NFL Picks New Orleans Saints vs Buffalo Bills Predictions & Picks

New Orleans Saints vs Buffalo Bills Predictions & Picks

Thursday night action in the NFL is going to be wrapped up at Mercedes Benz Superdome where New Orleans Saints welcome Buffalo Bills. In terms of the latest betting lines, visitors were given the advantage, but Saints have been quite unpredictable throughout the whole campaign so far. Which side is going to be more successful? Read on our betting picks and predictions below.

New Orleans Saints vs Buffalo Bills Predictions

November 25th 2021 – 8:20 ET


rsz betmgm - New Orleans Saints vs Buffalo Bills Predictions & Picks

Odds -110

$20 wager returns $38

See Full Sportsbook Review

BET HERE


Top Betting Offer To Take Advantage Today

rsz betmgm - New Orleans Saints vs Buffalo Bills Predictions & Picks
  • Register for a new BetMGM account & deposit
     

  • Place your first bet up to $1,000 risk-free!

  • Get a refund up to $1,000 if you lose

(New User Bonus. 21+; Valid Only NJ, IA & WY; T&Cs Apply.)


rsz betmgm - New Orleans Saints vs Buffalo Bills Predictions & Picks

Odds -110

$20 wager returns $39

See Full Sportsbook Review

BET HERE

Tip Reasoning

  • Both teams need high win rate in remaining weeks to keep good chances of reaching playoffs
  • New Orleans have lost three games in a row prior to this clash
  • They are doing well on the road so far this season, winning three out of five games

Buffalo Bills have been unrecognizable in the last couple of weeks

Saints pretty much ruined all the good work from the opening two months. They are entering this duel with horrible streak of three consecutive defeats, which pushed them down to 2nd place on the NFC South. Tampa Bay Buccaneers have two victory advantage at the moment, so win rate has to be high in the remaining weeks. New Orleans Saints allowed 40 points last weekend to Philadelphia and easily lost the encounter. Trevor Siemian stepped in as reserve QB and he hasn’t been doing that well, being at 56% completion rate, 920 passing yards, eight TD’s and two interceptions. Back line is allowing around 22 points to opponents on average, as well as 342 yards per duel. The most recent duel against the Bills was played four years ago and NO won it 47:10. Similar scenario happened with Bills, as their advantage over Patriots in AFC East melted quickly. They were defeated in three out of the last five games. With visitors having poor spirits, we fancy the home win in +6.5 spread betting as pick number one.

Game Totals Prediction

As for the option number two, the last two games for Buffalo ended with absurdly high number of points, as their defense is not doing that well. We are feeling comfortable with the Over 45.5 option here at -110.

Q. What time is Saints v Bills game starts?

Thursday 8:20 ET

Q. What ground is the Saints v Bills played at?

Mercedes Benz Superdome

Q. What are the odds on Saints winning?

+218 (Odds subject to chance)

Q. What are the odds on Bills winning?

-263 (Odds subject to change)

Top Betting Offers In New Jersey

rsz betmgm - New Orleans Saints vs Buffalo Bills Predictions & Picks
  • Register for a new BetMGM account & deposit
     

  • Place your first bet up to $1,000 risk-free!

  • Get a refund up to $1,000 if you lose

(New User Bonus. 21+; Valid Only NJ, IA & WY; T&Cs Apply.)

Caesars rzs - New Orleans Saints vs Buffalo Bills Predictions & Picks
  • Register for a new Caesars account using promo code: SB4YRF & deposit
     

  • Place your first bet!

  • Get a First Bet Match Up To $1001

(New User Bonus. 21+; Valid Only NJ & IA; T&Cs Apply.)

rsz sugarhouse - New Orleans Saints vs Buffalo Bills Predictions & Picks
  • Register and create a new account using promot code: 250MATCH

  • Make your first deposit

  • Get a 100% matched bonus up to $250!

(New User Bonus. 21+; Valid Only NJ & IA; T&Cs Apply.)

Unibet - New Orleans Saints vs Buffalo Bills Predictions & Picks
  • Click on the ‘Claim Here’ button below

  • Make your first deposit

  • Get $500 Risk Free Bet

(New User Bonus. 21+; Valid Only NJ & IA; T&Cs Apply.)

  • Sign up, deposit $10 more to your bet365 account

  • Bet365 will match your qualifying deposit in Bet Credits when you place qualifying bets to the same value and are settled.

  • Get up $500 in Bet Credits!

(New Customer Only. 21+; Valid Only NJ; Min odds and bet exclusions apply. Bet Credit risk excluded from return. T&Cs, time limits and exclusions apply.)

Previous articleEast Carolina Pirates vs Cincinnati Bearcats Predictions & Picks
Next articleNFL Parlay Picks: Our +256 Thursday Football Parlay